You can now find synthetic socks that are designed to get rid of any moisture and keep your feet drier than, say cotton and wool socks do. If you sweat often, change your socks often. When you’re at home, go without socks and shoes, giving your feet a chance to breathe. Also, strip the shoes and socks off quickly after a workout. Shoes make a difference in preventing toenail fungus as well. Alternate close-toed and open-toed shoes to allow your feet some oxygen every now and then.